Moderator: ofonorow
Saw wrote:Has she had her homocysteine checked, according to Kilmer McCully high homocysteine plays a role in forming oxy-cholesterols.
Beside lipoproteins, certain metabolic disorders, such asdiabetes and homocystinuria, are also associated with the development of CVD. Despite differences in the underlying pathomechanism, all these mechanisms share a common feature: they lead to a thickening of the vascular wall and thereby can counteract the increased permeability in ascorbate deficiency. In addition to these genetic disorders, the evolutionary pressure from scurvy also favored certain metabolic countermeasures.
Homocystinuric angiopathy Homocystinuria is characterized by the accumulation of homocyst(e)ine and a variety of its metabolic derivatives in the plasma, the tissues and the urine as the result of decreased homocysteine catabolism.18 Elevated plasma concentrations of homocyst(e)ine and its derivatives damage the endothelial cells throughout the arterial and venous system. Thus homocystinuria is characterized by peripheral vascular disease and thromboembolism. These clinical manifestations have been estimated to occur in 30 per cent of the patients before the age of 20 and in 60 per cent of the patients before the age of 40.19
Ascorbate supplementation prevents homocystinuric angiopathy and other clinical complications of this disease by increasing the rate of homocysteine catabolism.20 Thus, ascorbate deficiency unmasks a variety of individual genetic predispositions that lead to CVD in different ways. These genetic disorders were conserved during evolution largely because of their association with mechanisms that lead to the thickening of the vascular wall. Moreover, since ascorbate deficiency is the underlying cause of these diseases, ascorbate supplementation is the universal therapy.
ofonorow wrote:The Pauling/Rath unified theory of cardiovascular disease uses the fact that homocysteine is inversely related to vitamin C as evidence of their theory:
I really wished I could confirm that evidence from my experience, but despite high dose vitamin C since more than 3 years my homocysteine misbehaves. Also Lp(a) went a bid down only to come up again. But I'll persist and prove the theory true, ultimately
Johnwen wrote: You have Stage 1 kidney disease which isn't all that bad!
The prognosis of patients with chronic kidney disease is guarded as epidemiological data has shown that all cause mortality (the overall death rate) increases as kidney function decreases.[16] The leading cause of death in patients with chronic kidney disease is cardiovascular disease, regardless of whether there is progression to stage 5. [16][17][18]
Johnwen wrote: I need this info to calculate kidney function from your other test results.
Johnwen wrote: You have all the indications of a chronic infection and thinking about it I would still get retested for malaria.
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