Hypoascorbemia induces atherosclerosis and vascular deposition of lipoprotein(a) in transgenic mice
Posted: Wed Aug 19, 2015 6:16 am
Hypoascorbemia induces atherosclerosis and vascular deposition of lipoprotein(a) in transgenic mice
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447075/
It was noticed early on (at least a decade ago) after they first created mice with the GULO defect preventing them from making vitamin C - that these mice would suffer atherosclerosis.
This connection with Lp(a) is interesting as the mice (which normally make their own vitamin C) shouldn't have had an evolutionary reason to make Lp(a) - one would think.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447075/
It was noticed early on (at least a decade ago) after they first created mice with the GULO defect preventing them from making vitamin C - that these mice would suffer atherosclerosis.
This connection with Lp(a) is interesting as the mice (which normally make their own vitamin C) shouldn't have had an evolutionary reason to make Lp(a) - one would think.