Patients at low risk for coronary heart disease probably do not benefit from and may even be harmed by aspirin

The discussion of the Linus Pauling vitamin C/lysine invention for chronic scurvy

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Patients at low risk for coronary heart disease probably do not benefit from and may even be harmed by aspirin

Post Number:#1  Post by ofonorow » Sun May 29, 2022 11:29 am

Aspirin for the Primary Prevention of Cardiovascular Events: A Summary of the Evidence for the U.S. Preventive Services Task Force
https://www.acpjournals.org/doi/full/10.7326/0003-4819-136-2-200201150-00016

For patients without known cardiovascular disease who are similar to those enrolled in the 5 large primary prevention trials, our systematic review suggests that aspirin chemoprevention reduces myocardial infarction but has no effect on ischemic stroke or all-cause mortality over 5 years. Aspirin therapy also increases the risk for gastrointestinal bleeding and hemorrhagic stroke. Aspirin chemoprevention is probably beneficial for patients who have no previous diagnosis of cardiovascular disease but are at high risk for developing coronary heart disease in the next 5 years. Conversely, patients at low risk for coronary heart disease probably do not benefit from and may even be harmed by aspirin because the risk for adverse events may exceed the benefits of chemoprevention (6, 29).




Gastrointestinal Bleeding

Aspirin increased the rates of gastrointestinal bleeding in all 5 primary prevention trials. Detection of events, definition of a “significant” bleeding event, and reporting of location of upper gastrointestinal bleeding varied across trials (Table 5).
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Re: Patients at low risk for coronary heart disease probably do not benefit from and may even be harmed by aspirin

Post Number:#2  Post by eDOC » Tue Jun 07, 2022 5:49 am

It's not just the GI bleed quoted in the article cited, that even a colored rookie like me knows.

It's an imbalance in PG homeostasis.

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