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tpg82 wrote:I haven't started on megadosing VC yet, but I am considering it due to the problems I have been having with gallstones and digestive problems in general. Is there any evidence that gallstone pain and gas can be cured by VC therapy? Will oral VC cause more problems? I want to do whatever I can to avoid removal of my gallbladder, but sometimes the attacks are more painful than I care to endure. What can I expect from VC and what doses must I use it in order to feel better? Please help!
Gineter wrote:The activity of the cholesterol 7 alpha-hydroxylating system containing cyto-chrome P-450 is depressed in the liver of guinea-pigs with chronic marginal vitamin C deficiency. Slowing-down of this rate-limiting reaction of cholesterol transformation to bile acids causes cholesterol accumulation in the liver, blood plasma and arteries, increase in the index total: HDL cholesterol, prolongation of plasma cholesterol half-life, increase in the index cholesterol: bile acids in the gall-bladder bile, cholesterol gallstone formation and atheromatous changes on coronary arteries in guinea-pigs with long-lasting marginal vitamin C deficiency.
The most effective means for preventing these changes are vitamin C doses ensuring maximal steady-state levels of ascorbate in the tissues. In most of hypercholesterolemic persons with a low vitamin C status, the administration of ascorbic acid in doses 500-1000 mg per day lowers total cholesterol concentration in blood plasma.
This effect may be reinforced through a simultaneous administration of bile acids sequestrants, such as cholestyramine or pectin. In every form of hypercholesterolemia therapy (dietary and/or pharmacological), an adequate vitamin C supply should be ensured in doses capable of creating maximal steady-state levels of ascorbate in human tissues.
tpg82 wrote:I haven't started on megadosing VC yet, but I am considering it due to the problems I have been having with gallstones and digestive problems in general. Is there any evidence that gallstone pain and gas can be cured by VC therapy? Will oral VC cause more problems? I want to do whatever I can to avoid removal of my gallbladder, but sometimes the attacks are more painful than I care to endure. What can I expect from VC and what doses must I use it in order to feel better? Please help!
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