Post
by ofonorow » Mon Jul 09, 2012 6:23 am
Thanks for finding that report.
From a cursory reading, it seems that we now know that before 1993, there were "no cautions" about vitamin C re: G6PD, and only two case reports. (One from Indian children attributed to taking a lot of "fizzy" drinks!?
This case is interesting, as 40 g IVs (three times weekly) and 20-30 g vitamin C by mouth over the course of a month had no effect on an HIV+ black man with the sickle cell trait. (Later found to have the G6PD deficiency.)
Then, supposedly a single 80 g IV dose was thought to cause the blood breakdown event, (symptom: dark urine), which was corrected with fluids and folic acid?
My first question is what happened that precipitated the decision to double the IV dosage from 40 to 80 g? (This information would be helpful in understanding whether the increased vitamin C, or the underlying condition being treated was at fault.)
Owen R. Fonorow
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