Overall, the trial demonstrated that for patients with sepsis admitted to the ICU who were on vasopressor therapy, intravenous vitamin C was associated with a higher risk of death or persistent organ dysfunction.
lies, more lies? in the periodicals physicians read.... Are doctors really this gullible?
So what is wrong with this study? Sounds impressive...Intravenous vitamin C increases mortality and organ dysfunction in sepsis patientshttps://www.physiciansweekly.com/intrav ... -patients/
Evidence rating is "excellent?"So what is vasotherapy? Apparently drugs that raise blood pressure. Did they all get the same vasotherapy drug? Unsaid and unknown. Maybe we should trust them...https://www.frontiersin.org/articles/10 ... 00317/fullConclusions
Neurological dysfunction is frequent during sepsis. Both sepsis and high dose vasopressor therapy may negatively impact cerebral perfusion and/or oxygenation. The best way to monitor and to manage patients suffering from sepsis-induced neurological dysfunction remains to be elucidated.
Results
A total of 872 patients underwent randomization (435 to the vitamin C group and 437 to the control group). The primary outcome occurred in 191 of 429 patients (44.5%) in the vitamin C group and in 167 of 434 patients (38.5%) in the control group (risk ratio, 1.21; 95% confidence interval [CI], 1.04 to 1.40; P=0.01). At 28 days, death had occurred in 152 of 429 patients (35.4%) in the vitamin C group and in 137 of 434 patients (31.6%) in the placebo group (risk ratio, 1.17; 95% CI, 0.98 to 1.40) and persistent organ dysfunction in 39 of 429 patients (9.1%) and 30 of 434 patients (6.9%), respectively (risk ratio, 1.30; 95% CI, 0.83 to 2.05). Findings were similar in the two groups regarding organ-dysfunction scores, biomarkers, 6-month survival, health-related quality of life, stage 3 acute kidney injury, and hypoglycemic episodes. In the vitamin C group, one patient had a severe hypoglycemic episode and another had a serious anaphylaxis event.