Abrupt termination of vitamin C from ICU patients may increase mortality
Posted: Wed Dec 21, 2022 11:46 am
Abrupt termination of vitamin C from ICU patients may increase mortality: secondary analysis of the LOVIT trial
https://www.nature.com/articles/s41430-022-01254-8
https://www.nature.com/articles/s41430-022-01254-8
The LOVIT trial examined the effect of vitamin C on sepsis patients, and concluded that in adults with sepsis receiving vasopressor therapy in the ICU, those who received 4-day intravenous vitamin C had a higher risk of death or persistent organ dysfunction at 28 days than those who received placebo. The aim of this study was to determine whether the abrupt termination of vitamin C administration could explain the increased mortality in the vitamin C group.