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Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone and Outcomes in Septic Shock

Posted: Sun Jan 19, 2020 6:56 am
by C-can
Seems like they didn't get the same 87% miracle with 1.5g every 6hrs as the other study.

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In this randomized clinical trial that included 216 patients with septic shock, treatment with intravenous vitamin C, hydrocortisone, and thiamine, compared with intravenous hydrocortisone alone, did not significantly improve the duration of time alive and free of vasopressor administration over 7 days (122.1 hours vs 124.6 hours, respectively).

https://jamanetwork.com/journals/jama/f ... le/2759414

Re: Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone and Outcomes in Septic Shock

Posted: Sun Jan 19, 2020 11:14 am
by C-can
I posted this before I saw Owen had already posted the relevant rebuttal in General discussion. So they used patients too far along in sepsis to replicate the positive results seen by Dr. Marik.

viewtopic.php?f=3&t=14693