Inhibitory effect of vitamin C on intrinsic aging in human dermal fibroblasts and hairless mice

[ofonorow]

https://link.springer.com/article/10.1007/s10068-017-0252-6

In the middle-aged (MA) mice, oral administration of vitamin C significantly inhibited wrinkle formation, skin atrophy, and loss of elasticity through increasing collagen and elastic fiber. The increase in transepidermal water loss and the decrease in skin hydration were recovered by vitamin C treatment in the MA mice. Overall, vitamin C effectively prevents cellular senescence in vitro and in vivo suggesting it has protective potential against natural aging of the skin.