ofonorow wrote:The Pauling therapy has never been studied !!!
That fact is one of the greatest tragedies of our times ( but has also kept most major hospitals from going bankrupt)
So what we think we know is from the reports of those diagnosed with severe cardiovascular disease. Most of these reports are kept by me, but there are hundreds from Tower Laboratories too.
Adding proline seems to make the Lp(a) binding inhibitors work faster and better.
There are two theoretical reasons why proline works.
#1 - the collagen protein is a triple helix and the helix strand contains both lysine and proline. (In fact, when the arterial wall breaks, it is the broken strands of proline and lysine that the Lp(a) molecules adhere to beginning the atherosclerotic process.) So both lysine and proline are building blocks or raw materials of collagen, and vitamin C is required as a catalyst to make collagen.
#2 - After Pauling died, the Univ of Chicago discovered the "proline binding sites" on the Lp(a) molecule, analogous to the Lysine Binding sites that Pauling knew about. This helps to explain why proline is also an effective Lp(a) binding inhibitor, and may also work to prevent the formation of Lp(a) in the liver. All this is in my book Practicing Medicine.
The issue is that while lysine is "essential" - meaning the body doesn't make it and we must get at least 1 gram daily in our diets, proline is "non essential" (poor terminology) because our body makes it. (In fact is it "more essential" because the machinery to build it has not been lost over the course of evolution.) Anyway, I think that one possibility that explains the increased incidence of cardiovascular disease as we age, other than wear and tear on the arteries, is that our cells make less proline as we age.
Thanks
I feel like I've been mislead my whole life.
so the key to avoiding CAD and maybe lots of diseases is vit C intake?(over 100mg/kg)
so as long as I intake a bunch of VitC, I won't get CAD?
or do other health concerns increase chance of CAD,
Like is a 400lbs guy who takes 100+mg vitC/kg body weight,(20K mg vit C./day) less likely to get CAD than a 180lbs/`12% bodyfat guy who gets the RDA of vitamin C?
is that 400lbs (40%BF) guy have a similar chance of CAD as a 12% bf guy who gets the same amount of vit C?