2010 version of the 2009 Jaffee lecture originally posted. This is a better explanation of how/why vitamin C works!
Russell Jaffe, MD, PhD discusses safe detox methods IAOMT 2010 Galloway http://www.youtube.com/watch?v=8fnfa48mjL8"Safer removal of toxic metals"
"complexing, mobilizing and safely excreting toxic metals"
"ascorbate loves to scavenge toxic metals.. double valent catons - such as lead, mercury etc will bind to ascorbate.
Original contribution: how much toxic metal can a gram (5 mmol) of ascorbate bind with a toxic metals. Conservative methods find a gram of ascorbate finds 10 mcg of Hg.
Ascorbate is the molecule cells like most... Cells accumlate ascorbate levels 30x over plasma
Typical populaton "calbibrates (ascorbate requirement) more than 10 g, and less than 130 g of ascorbate.
Ascorbate safely protects, mobilizes, complexes, and excretes toxic minerals.
60% in urine, 30% in feces, 10% in sweat
Healthy levels of magnesium/zinc are synergistic and assist ascorbate chelate (He speculates
because these promote a more alkaline state) How many in healthy alkaline state? Very few.
Sulphur sources in diet can help ascorbate (conjegation) toxic metals (lower the burden)
Objective: reduce oxidative stress
Always means buffered form of ascorbate (never acidic form) in this talk
Can find out alkaline status with First Morning Urine. Test for metabolic acidosis. 6.5 to 7.5 is
healthy range.
selenomethionine - the beneficial form of selenium - other forms do not work well.
To enhance extretion - selenomethionine and sulfur rich foods (eggs, onions, garlic, ginger, brassica sprouts)
sulfur rich foods promote GSH store
metalothionein - natures protection for heavy metals - combines with metal, frees mg/zinc, lower levels better.
ascorbate is the most effective way to raise GSH (Alton Miester was right all along) (min 27)
Minute 35 -
Ascorbate Calibration method.
Healty - 1.5 g every 15 min
Moderately ill - 3 g every 15 min
Chronically ill - 6 - 12 g every 15 min
for two hours until "evacuation" -
contrast with bowel tolerance, slow buildup, which can recirculate toxins! This will flush toxins.
http://www.PERQUE.com - ascorbate calibration procedure
After discussion of Sulphur foods - requirement,
talks about bioflavonoids/polyphenols
Lipoic acid protects the nucleus (antioxidant) (around min 52 )
Discussion why " ascorbate is never a pro-oxidant in biological systems. " (min 53)
Owen R. Fonorow
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