https://www.medpagetoday.com/criticalcare/sepsis/99248
Headline is that vitamin C now harms sepsis patients! (Notice that you can't easily read this paper)
Moderators: ofonorow, popnowlin
Overall, the trial demonstrated that for patients with sepsis admitted to the ICU who were on vasopressor therapy, intravenous vitamin C was associated with a higher risk of death or persistent organ dysfunction.
Neurological dysfunction is frequent during sepsis. Both sepsis and high dose vasopressor therapy may negatively impact cerebral perfusion and/or oxygenation. The best way to monitor and to manage patients suffering from sepsis-induced neurological dysfunction remains to be elucidated.
Results
A total of 872 patients underwent randomization (435 to the vitamin C group and 437 to the control group). The primary outcome occurred in 191 of 429 patients (44.5%) in the vitamin C group and in 167 of 434 patients (38.5%) in the control group (risk ratio, 1.21; 95% confidence interval [CI], 1.04 to 1.40; P=0.01). At 28 days, death had occurred in 152 of 429 patients (35.4%) in the vitamin C group and in 137 of 434 patients (31.6%) in the placebo group (risk ratio, 1.17; 95% CI, 0.98 to 1.40) and persistent organ dysfunction in 39 of 429 patients (9.1%) and 30 of 434 patients (6.9%), respectively (risk ratio, 1.30; 95% CI, 0.83 to 2.05). Findings were similar in the two groups regarding organ-dysfunction scores, biomarkers, 6-month survival, health-related quality of life, stage 3 acute kidney injury, and hypoglycemic episodes. In the vitamin C group, one patient had a severe hypoglycemic episode and another had a serious anaphylaxis event.
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