Post
by pamojja » Sat Dec 20, 2025 4:59 am
Not meant as medical advice: but many online suggest about 70 ng/mg as optimal for many health outcomes from the literature. My lab initially had a normal range between 30 and 100 ng/ml, so exactly in the middle of that.
However, 'normal' ranges from many labs are statistical constructs. About 95% of all test results of a lab are considered 'normal', the upper and lower 2.5% considered outside of normal. Due to such statistical calculations, my lab decreased the 'normal' range to between 30 and 70 ng/ml too, some years ago.
According to literature, the first toxicity sign for too high blood levels is above normal calcium levels, which in real observations occurred only around 200 ng/ml 25(OH)D3 serum levels. Another early marker for overdose would be suppressed PTH.
Accidentally, I once overshoot mine to 135 ng/ml, and coincidentally that correlated with my last and most difficult to reach remission of Post-Exertional-Malaises. In 3-years intervals already before remissions of symptoms of COPD, and from a walking-disability from PAD. With an average Vitamin 25(OH)D3 serum level of 70 ng/ml the last 17 years. Serum Calcium never went too high, but too low at times.
Pauling didn't recommend vitamin D. Allegedly because at that time only the health problematic vitamin D2 was available, and not the advised vitamin D3.
There is also a really high dose vitamin D3 protocol against MS. But advised only under close supervision of a physician, with tight monitoring of serum Calcium and PTH, AND avoiding Calcium containing foods.