Medicine to make self-carrying newsletter
October 2024
Alzheimer's, MS, Parkinson's, ... –
Effective agents in neurodegenerative diseases Part 2
Newsletter Contribution by Dominik Dietz
To the YouTube video from
Dr. Hartmut Fischer
In our continued efforts to develop comprehensive solutions to the challenges of neurodegenerative diseases, we are continuing our series of articles with the second part, in which we focus on further innovative and effective therapeutic means.
In the first part, which is taking Alzheimer's, Parkinson's, MS & Co. –
Part 1 is available, we have illuminated in detail basic means such as DMSO, medicinal plant sinks, choline, galactose, melatonin and GABA. In this continuation article, we focus on additional, promising substances such as lithium chloride, the electrolyte mixture,
acetylcysteine, 5-HMF, theophylline, N-acetyl glucosamine and alpha-lipoic acid. Each of these funds is presented in detail, illuminating both their specific mechanisms of action and their potential role in the relief and treatment of symptoms of neurodegenerative conditions. The aim is to create a deeper understanding of the importance of these advanced therapeutic means and to promote their use in Integrative Medicine.
Lithium – Life extension and dementia prevention
Lithium, known for its preventive and therapeutic effects, especially in the field of dementia prevention and anti-aging, is traditionally used in high doses in neurology and psychiatry. However, recent research shows that even low-dose lithium, about 10 mg daily, offers amazing health benefits. This dosage is far below the amount commonly used in the medicine and aims to minimize side effects and increase accessibility.
How does low-dose lithium work? Low-dose lithium interacts with the central nervous system to regulate synapse activity and thus provides protection against neurodegenerative diseases such as Alzheimer's, MS, Parkinson's, etc. It is believed that lithium also has balancing effects on the vegetative nervous system and slows down age-related degradation processes in the brain.
Application and dosage recommendations:
Electrolyte mixture: A simple method to ensure the exact dosage is the use of an electrolyte mixture of e.g.
www.alchemist.de, which contains exactly 10 mg of lithium per 2.5 grams, among other minerals. This mixture can be easily dissolved in water and drink daily.
Lithium Chlorinity: For those who prefer an even easier application, there is a 9% lithium chloride solution, which also provides 10 mg of lithium per 10 drops. These drops are easy to handle and can be taken daily.
Precision in dosage: The exact determination of the lithium dose can be challenging, since usual jewelry scales often only provide an accuracy of two after the decimal point. Therefore, we recommend either the premixed solutions or the use of more accurate scales when weighing lithium salts themselves.
For detailed instructions on how to use lithium and other information about its effects and benefits, we recommend the following video on our YouTube channel:
https://youtu.be/RVkYYmm zwk feature shared
This simple, cost-effective method makes the daily intake of low-dose lithium accessible and practical, and provides an excellent opportunity to improve brain health and overall quality of life.
Acetylcysteine (NAC) – An all-rounder in the treatment and prevention of neurodegenerative diseases
Acetylcysteine, also known as NAC, is increasingly attracting attention in health circles, not only as a traditional mucous release, but as a versatile remedy that goes far beyond that. In a past circular article (
https://medizinzumselbermachen.de/rundb ... -reinform/ ) has already been pointed out the potential of acetylcysteine, in particular its diverse applications and capabilities. NAC is an integral part of the health toolbox, accessible to all forms of application – from external and internal applications to injections and infusions.
In the past, often only marketed as a simple mucous remover, acetylcysteine has found a new role in integrative medicine. It is now also used in neurodegenerative diseases such as Alzheimer's and Parkinson's disease, thanks to its ability to increase glutathione levels and protect against free radicals. It also supports the body's immune system, reduces harmful blood lipids and provides protection for the heart and vessels – all crucial factors in the prevention and treatment of neurodegenerative conditions.
NAC, a white powder in pharmaceutical purity, I refer, for example, from
www.alchemist.de to the quality standards Ph. Eur., USP, Food Grade. The purity of the product ensures that no unwanted industrial additives are consumed, which are often found in ready-made preparations. As a result, the effect remains genuine and optimally possible, which is of great importance, especially in neurodegenerative diseases.
The application is relatively simple: the dosage of acetylcysteine is done effortlessly with the help of a cost-effective milligram scale. For a typical single dose, you measure 500 to 800 mg, replace it in warm water and drink the solution. This method has proven to be acceptable in children even in taste. If desired, you can add a few drops of DMSO to the solution to increase effectiveness. The dose can be easily adapted to individual needs and can also be taken several times a day as needed. Thanks to their simple preparation and flexible dosage, NAC is ideally suited for everyday use, both in standardised and special medical protocols, for example for local injections or systemic infusions for serious health problems.
This approach to the use of acetylcysteine is particularly well suited to the advanced treatment of neurodegenerative diseases, an issue that will be further discussed in future newsletter contributions.
5-HMF – Important therapy component for neurodegenerative diseases
5-Hydroxymethylfurfural (5-HMF) is a small molecular weight, which is naturally found in honey and indicates its aging. In addition to its familiar presence in beekeeping, 5-HMF has gained medically relevance, especially through its beneficial effects on mitochondrial function. These properties predestine it as a prospective supporter in the treatment of neurodegenerative diseases, in particular by its neuroprotective effects, which include the protection of neuronal cells and the promotion of nerve regeneration.
Research shows that 5-HMF has a regenerative effect on the inner mitochondrial membrane. This is crucial because mitochondria play a central role in cell energy production and whose health is directly linked to neurodegenerative diseases such as Alzheimer's, Parkinson's, multiple sclerosis, ... 5-HMF not only contributes to increasing oxygen absorption and energy production, but also protects against cellular damage caused by free radicals and thus supports cellular integrity in neurological systems.
In addition to the general support of mitochondrial health, 5-HMF is used specifically in the pre- and post-treatment of complicated surgical procedures to reduce stress and promote the regeneration process. Its ability to provide fast and effective mitochondrial support makes it a valuable agent in integrative medical practice, especially for mitigation and prevention of neurodegenerative conditions.
For therapeutic purposes, a 30% solution of 5-HMF is used in DMSO. The recommended dose is 20 drops of this solution, dissolved in a glass of water that corresponds to about 300 mg of 5 HMF. This dosage can be adjusted to the symptoms as needed and severity. In acute conditions, such as after surgery or increased stress, the dose may be increased or applied twice daily.
5-HMF in the required pharmaceutical quality is available through specialist suppliers such as . There it is possible to buy the 30% solution in DMSO which is easy to dose and apply. This formulation allows the effective use of the neuroprotective and regenerative properties of 5-HMF, which makes it an essential component for the treatment and management of neurodegenerative diseases.
Detailed information about 5-HMF can be found in the DMSO & Co. Book series that offers deeper insights into its diverse applications and effects.
Theophyllin – Ancient means, new hope for MS and neurodegeneration
Theophyllin, an ancient component of tea and biochemical sibling of caffeine, is experiencing a renaissance in medical research. Originally used as the main means for the treatment of respiratory diseases, new scientific findings reveal its potential to support neurodegenerative diseases such as multiple sclerosis.
Recent studies, including works by Johannes Gutenberg University Mainz and the Université de Fribourg, it was discovered that theophylline can make a significant contribution to the regeneration of myelin sheaths. These are essential for nerve function and their restoration is a key aspect in the treatment of neurodegenerative conditions. Studies published in Nature Communications have shown that theophylline activates the histon deacetylase, a key mechanism that allows the reconstruction of the myelin departure. It is particularly noteworthy that the doses required for this effect are significantly lower than those traditionally used to treat lung obstructions, thereby minimizing the risk of side effects.
For therapeutic purposes it is recommended to start with a lower dose of 50 mg of theophylline daily, which is dissolved in water. This starting dose can be slowly increased according to individual needs and tolerability. It is recommended to gradually increase the dose, up to a maximum of 100 mg daily, depending on the physical response.
Theophyllin is available in various forms, including tablets, capsules and ampoules. However, the pure, powdered form can be preferred for precise dosing and to simplify the absorption. This can be obtained at
www.alchemist.de, for example.
For people who want to adapt to the bitterness of the theophylline, a mixture with xylitol can be helpful. Xylit not only masks the bitterness, but also promotes the butyrate-causing bacteria in the intestine, which can have additional neuroprotective advantages. The recommended mixture consists of 2.5% theophylline and xylitol, with 2 grams of this mixture containing 50 mg of theophylline. This mix makes it easy to accurate dosage and can be consumed throughout the day in small swallowing to maximize the effect and minimize side effects.
It is advisable to start taking theophylline in the morning to avoid possible effects on sleep. In addition, a step-by-step introduction can help to assess the individual tolerance and adjust the dosage accordingly.
Theophylline, once a common asthma drug, is now being researched for its potential neuroregenerative properties. These discoveries open up new possibilities in the treatment of MS and other neurodegenerative states, with further research needed to determine the exact mechanisms and optimal application protocols.
N-acetyl-glucosamine – A key molecule for myelin regeneration in neurodegenerative diseases
N-acetyl-glucosamine and its relative glucosamine are more than just simple sugar. These substances, which are biochemically derived from glucose and are characterized by an additional amino group, perform numerous important functions in our body.
From joint care to skin health, glucosamine is known for its wide application areas. However, beyond these well-known functions, an even more fascinating aspect of N-acetyl-glucosamine is hidden: its potential in the treatment of neurodegenerative conditions such as multiple sclerosis, Alzheimer's and Parkinson's disease. This is due in particular to its ability to regenerate the myelin sheaths that envelop the nerve fibers and thus play a central role in neuronal health and function.
Research on model organisms has shown that N-acetyl glucosamine not only has life-prolonging properties, but also actively contributes to the reduction of inflammatory markers in the blood. In addition, it strengthens the body's own defence mechanisms against toxic protein aggregation, which plays a role in neurodegenerative diseases. Researchers at the Max Planck Institute for Biology of Ageing in Cologne, for example, have discovered that supplementation with N-acetyl-glucoamine in nematodes can reduce the harmful clumping of proteins and even prolong the lifespan of the animals.
Another revealing detail is that N-acetyl-glucosamine is a natural component of human breast milk, an indicator of its important function in the development and maintenance of healthy neural structures. Clinical studies indicate that supplementing with N-acetyl-glucosamine can promote the myelinisation of the nerve fibers and thus contribute to the repair of multiple sclerosis.
For therapeutic applications, N-acetyl-glucosamine is typically recommended in doses of 600 to 1500 milligrams daily, depending on the specific needs and states of the individual. It is available in powder form and thus enables precise dosing and versatile use – whether dissolved in water for oral consumption or as a component of infusion solutions.
N-acetyl-glucosamine, available in pure form, for example at
www.alchemist.de , is an essential component in the treatment of neurodegenerative diseases and effectively contributes to the regeneration of essential nerve structures.
For further information and a detailed description of scientific research on N-acetyl-glucosamine and its importance in the treatment of neurodegenerative diseases, please refer to the following newsletter Article:
https://medizinzumselbermachen.de/rundb ... neurodeen/
Alpha-lipoic acid – A versatile antioxidant for nerve protection and more
Alpha-lipoic acid, also known as thiooctic acid or ALA, is a sulfurous fatty acid that plays a key role in mitochondrial energy metabolism. Since its therapeutic introduction in 1966, ALA has found widespread recognition due to its ability to act as a hydrogen carriers and contain two sulfur atoms in each molecule.
ALA is not only known as an antioxidant, but also as an effective chelant, especially in its reduced form, which forms strong complex bonds with heavy metals such as mercury. This property allows an efficient excretion via the liver-gall path. Their fat solubility allows the alpha lipoic acid to reach the central nervous system, which distinguishes it from many water-soluble chelating drugs.
The versatile therapeutic applications of ALA include the treatment of neurodegeneration such as polyneuropathy and dementia, as well as their use as a powerful antioxidant in situations such as stress, performance training, surgery, rehabilitation and in chronic and acute infections. The synergistic combination of ALA with other active ingredients such as 5-HMF can further increase their effectiveness.
The therapeutic form of ALA, especially R-lipoic acid, is the naturally occurring isomer form, while the S-lipoic acid, a product of industrial production, is often considered less effective. For therapeutic applications, therefore, the use of the pure material R-lipoic acid in powder form, as offered by , for example, is preferable.
To prepare an infusion of alpha-lipoic acid, 600 mg of R-lipoic acid is initially suspended in low water. Then add 300 mg potassium hydrogen carbonate or 250 mg of sodium hydrogen carbonate to neutralize the acid and increase the pH of the solution. This mixture is filtered with a sterile syringe filter and placed in a 250 ml saline infusion solution. In addition, 2 to 7.5 grams of DMSO and one ampoule of magnesium sulfate (10 %) can be added to improve blood flow and optimize the distribution of ALA to the nerve cells. Optionally, 1 ml of a 30% 5-HMF/DMSO solution can also be added to the infusion to enhance the effect.
For oral intake, alpha-lipoic acid should also be neutralized to avoid stomach irritation. For this purpose, 600 mg of ALA are mixed with at least 300 mg of potassium hydrogen carbonate. These components are stirred in low-heat water until no more gas bubbles form. The solution is then filled with water and can be drunk. This method protects the gastric mucosa and allows a gentle absorption of ALA.
For more detailed information and further application tips, please refer to the comprehensive newsletter article, which can be found at
https://medizinzumselbermachen.de/rundb ... 2023/nerve protection energy-antioxidation-multitalent-alpha-liponsaeure/.