help from docs with I/V experience - serious reaction
Posted: Fri Nov 15, 2013 12:13 pm
These docs were using DSM sodium ascorbate for i/v with the following description of events:
I refer to our telephone conversation pertaining to the incident of my brothers patients who have developed reaction while infusion ended up rushed to the emergency ward in the General Hospital.
In Brief i was informed by my brother as follows:-
60gram of sodium ascorbade reconstituted in 800 ml sodium chloride (normal saline) ended in reaction in his patient.
The patient is 58 years old with a CA prostate with bony metastasis ealier on antiandrogen therapy.
The product that was delivery to us namely sodium ascorbade (for IV) was compounded at the componding lab who have divided into 10gram in 50ml sterile syringes.
The reconstituted powder was mixed with IV parentovit. The infusion was over 1.5 hours.
At the middle of the infusion the patient developed sob, restlesness,chills and rigor. His Blood pressure was 80/60, tachycardia, pallor with cold extremities. Infusion ceased, replaced with n.s.l/m adrenaline three times, 1/m piriton, o2 givwenimmediately. Patient referred to hospital via ambulance. CBC - normal, blood sugar -19mmol. Patient comfortable but admitted for observation.
Question
Is this sodium ascorbade exclusively meant for IV use?
I was told by my brother that the product that he normally use for vit C IV were crystal clear, unlike your product ( 6 bottle of sodium ascorbade ) that you have confirmed that it can be used for IV. In fact your product turbid yellow upon constitution the powder does not dissolve completely. Sediments are still seen.
Please revert to me as soon as possible.
thank you