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Nicotine: The Wonder Drug
"The importance of nicotine's safety, especially its long-term safety, is related not only to its role
in the cessation of smoking but also to its potential role in the treatment of many clinical
conditions."
Alexander Glassman, M.D., Book Review of Nicotine Safety and Toxicity, Ed. by Neal L. Benowitz,
NY, Oxford Univ. Press, 1998, in The New England Journal of Medicine, 2/18/99.
Some of the already established pharmacologic applications of nicotine include: pain relief, relief of anxiety
and depression; improvement in concentration and performance in those with attention deficit hyperactivity
disorders; relief of some of the symptoms of acute schizophrenia; relief of some of the symptoms of
Tourette's syndrome; relief of some of the symptoms of Parkinson's disease; and relief of some of the
symptoms of Alzheimer's disease.
New, cutting-edge research indicates even greater medical applications for nicotine:
"This study demonstrates that nicotine stimulates recovery from brain damage and the results
are discussed in relation to neural mechanism and potential applications." (Brown RW, Gonzalez
CL, Whishaw IQ, Kolb B, Nicotine improvement of Morris water task performance after fimbria-fornix
lesion is blocked by mecamylamine, Behav Brain Research, Mar 15, 2001.)
The research, involving animal studies, showed that the nicotine agent created more new
blood vessels in blocked arteries than any other known growth factor. The new agent could be
used to treat failing hearts and limbs with poor circulation. It holds the potential for nonsurgical
heart by-pass procedures. (Company Press Release, Research Indicating That Nicotine Holds
Potential for Non-Surgical Heart By-Pass Procedures Honored by the American College of Cardiology,
3/17/00)
Nicotine might be a surprising alternative someday for treating stubborn forms of
tuberculosis The compound stopped the growth of tuberculosis in laboratory tests, even
when used in small quantities, said Saleh Naser, an associate professor of microbiology and
molecular biology at UCF.... Naser said nicotine worked better than about 10 other substances
also tested. ( Shocker: Villain nicotine slays TB, Robyn Suriano, Orlando Sentinel, 5/22/01).
In addition, nicotine can exert a neuroprotective effect by attenuation of AA-induced
upregulation of nNOS metabolism. These data may have therapeutic implication for the
treatment of acute spinal cord trauma. (Toborek M, Garrido R, Malecki A, Kaiser S, et al, Nicotine
Attenuates Arachidonic Acid-Induced Overexpression of Nitric Oxide Synthase in Cultured Spinal Cord
Neurons, Experimental Neurology, 161(2), Feb 2000).
According to a new study, nicotine may reduce cramping and other symptoms of colitis, a
painful intestinal disease that affects hundreds of thousands of people in the U.S. and millions
around the world. The study, published in the Annals of Internal Medicine (Mar 1, 1997),
could lead to better treatment for the estimated 320,000 people who suffer from ulcerative
colitis in the US. (AP, Mar 1, 1997).
Possible use of nicotine in the prevention of classical Kaposi's sarcoma with KS herpes virus
infection. (Goedert J, Vitale F, Lorenzo G, Romano N, National Cancer Institute, Classical Kaposi's
Sarcoma With KS Herpes Virus Infection: Reduced Risk with Cigarette Smoking, Proceedings of the
American Association for Cancer Research, Vol 42, March 2001).
Treatment of clinical depression. That could mean a whole new arena for new antidepressant
drugs. It's quite possible you could make derivatives of nicotine that wouldn't have the
medical complications of nicotine but could prove very useful in the treatment of clinical
depression. Dr. Alexander Glassman, chief of clinical psychopharmacology at Columbia University's New York State Psychiatric Institute (quoted in Kicking Habit Kicks Up Depression, Neil Sherman, HealthScout,
6/19/01).
Another thing Dr. Douglass mentions elsewhere for cognitive improvement is the Indian herb Bacopa. Anyway, interesting stuff.Effects of Transdermal Nicotine on Cognitive Performance in Down's
Syndrome http://193.78.190.200/13/tlj.htm
We investigated the effect of nicotine-agonistic stimulation with 5 mg
transdermal patches, compared with placebo, on cognitive performance in
five adults with the disorder. Improvements possibly related to attention and
information processing were seen for Downs syndrome patients compared
with healthy controls. Our preliminary findings are encouraging. More
benefits of nicotine. Of course, it is politically incorrect to say that this is a
benefit of smoking - only of the pharmaceutically-produced transdermal
nicotine, the one that is terribly addictive if delivered through cigarettes, but
not addictive at all, and even beneficial, when delivered through patches..
Antismoking nonsense aside, nicotine gets into the body regardless of the
means of delivery. And more evidence about the benefits seems to emerge quite
of-ten, though the small size of this study cannot certainly be taken as
conclusive.
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