I have also upped my vitamin C by 4 grams a day, and after I run out of my premixed drink mix (after tomorrow), I will begin separating out the arginine and lysine. Will also not mix with water to sip on all day. Sheesh, learning a lot.
I wanted to mention that I now do put my Cardio-C (or ascorbade) in a water bottle, plus more vitamin C powder, plus our new liposomal vitamin C, and do sip throughout the day. The taste is great, and I don't seem to require as much this way, and it is more in line with the Hickey/Roberts Dynamic Flow theory (ideally 500 mg every 3-4 hours keeps blood levels at their highest.)
Why if there is a loss in 4 hours of 50%? Well the Dr. Sherry Lewin experiments showed this drastic loss, but then it levels off to zero loss after 4 hours for a long period, so worst case, half the vitamin C is lost during the day. (So add 50% cushion if worried.) Also that 50% loss is based on concentration, a low concentration. At higher concentrations, such as filling a water bottle with a lot of vitamin C, the loss should be less.
As far as the lysine/arginine antagonism, we have been trying to track that down for years, and inside the cell there may indeed be such antagonisms, but lysine (and arginine) act outside the cell, in the blood stream w/r to Pauling therapy. Now if the idea is that they both compete for the same intestinal transporters, that might indicate separation, but in foods, they are combined so I don't really see any problem.