Gaert Van derbussche said the other day the protocol of Natto Bromelaine etc that McCullough sells does NOTHING against the spike
ZERO ...its basically snake oil
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Words from a non-practitioner are cheap. Practitioners try everything what possibly could help.Bromelain, a proteolytic enzyme sourced from the stem of pineapples [49], has been traditionally hailed for its healing and anti-inflammatory capabilities, particularly in cases of arthritis and injury. Of significance is bromelain's anticoagulant activity. It downregulates PGE-2 and thromboxane A2, promoting a relative prostacyclin abundance in platelets. Furthermore, it aids in fibrinolysis by promoting plasminogen conversion to plasmin and inhibiting platelet aggregation [50]. Kritis et al. demonstrated that bromelain can obstruct SARS-CoV-2's entry into cells by cleaving its spike protein and reducing ACE2 and TMPRSS2 expression [51]. This enzyme can also hydrolyze glycosidic linkages, which comprise spike protein's glycosidic shield that helps protect it from immune responses [52]. To attenuate inflammation, bromelain, in part, downregulates the pro-inflammatory prostaglandin E?2 (PGE-2) through inhibition of NF-kB and cyclooxygenase 2 and inhibits inflammatory mediators [51]. Thus, bromelain exerts multiple mechanisms of action against spike protein�s toxic effects and persistence. Bromelain has been used as a daily dosage of 200-2,000 mg; thus, 500 mg is a suggested initial dose [53]. Bromelain is mainly safe with low toxicity, but it can amplify bleeding risk and affect the absorption rate of several medications, potentially leading to drug interactions [54].
Curcumin, a polyphenol extracted from turmeric, is renowned for its anti-inflammatory properties and its ability to modulate inflammation during viral infections. Curcumin also supports fibrinolysis and the process of anticoagulation [51]. Beyond its traditionally recognized benefits, curcumin has shown promising antiviral actions against a wide range of viruses, including influenza, hepatitis, and notably, SARS-CoV-2 [55]. It achieves this by obstructing the spike protein's binding sites (ACE2 receptors and TMPRSS-2). Curcumin's anti-inflammatory effects are realized through inhibiting NF-?B signaling [56]. An in-silico study found that curcumin can inhibit the spike protein of the Omicron variant through interaction with its amino acids [57]. Randomized trials have consistently indicated decreases in high-sensitivity C-reactive protein (hs-CRP) and other markers of inflammation in situations involving spike protein-induced infections or injuries [58,59]. Curcumin is non-toxic at doses up to 8,000 mg a day [60]. Large doses, particularly with ill-absorbed formulations, can lead to gastric complications [61]. Enhanced absorption of curcumin is achieved in combination with piperine, or with nano or liposomal formulations, which are available as over-the-counter oral supplements. Doses vary widely depending on the formulation, but 500 mg twice a day has been shown to be a common and safe dosage regardless of curcumin type [61].
Hydroxychloroquine, a well-known FDA-approved antimalarial and anti-inflammatory, adds additional support for immunocompromised patients by inhibiting the binding of spike protein to human cells [62]. A real-time meta-analysis of 413 published peer-reviewed studies for hydroxychloroquine as a treatment for COVID-19, including a total of 529,687 patients, shows a statistically significant lower risk for mortality and hospitalization, along with accelerated viral clearance [63]. This effect was the strongest when patients were treated early, indicating the importance of early treatment. Since hydroxychloroquine accelerates viral clearance, it subsequently assists in spike protein removal, and it may be a great addition to base spike detoxification. This compound has been found to be well-tolerated, safe, and not associated with a risk of ventricular arrhythmia at a dose of 200 mg twice a day provided that the expected prolongation of QTc is managed along with other drugs with serial ECGs. Gastrointestinal symptoms may occur [64].
Colchicine, an FDA-approved alkaloid found in the plants Colchicum autumnale and Gloriosa superba, has been traditionally used in therapeutics for its anti-inflammatory properties [65]. This compound can reduce the risk of myocardial infarction and stroke [66]. Moreover, colchicine may reduce myocardial injury in the presence of spike protein [67]. Pleurodynia has been diagnosed post-COVID-19 vaccination and may be indicative of cardiac inflammation [68]. The COLCORONA trial demonstrated that colchicine was safe and had a favorable impact on COVID-19 and its immediate post-acute sequelae. In patients with PCR-confirmed COVID-19, colchicine lowered the rate of hospitalization and death compared to placebo [69]. A meta-analysis of five randomized trials, including a total of 16,048 patients, found that colchicine decreased COVID-19 severity and decreased C-reactive protein (CRP), indicating its potent anti-inflammatory effect in the presence of spike protein [70]. Thus, the addition of colchicine is indicated when a patient presents with pleurodynia post-COVID-19 vaccination or post-infection. Moreover, 0.5 mg twice daily has been shown to be a safe and effective dosage for the treatment of COVID-19 [65,69,70].
Additional compounds that may assist in spike protein detoxification and degradation include the following:
N-Acetylcysteine (NAC): It dissolves spike protein through the destruction of disulfide bonds and prevents binding at ACE2 [52,71,72].
Glutathione: It disrupts spike protein disulfide bonds [72].
Ivermectin: It binds and inhibits spike protein [73].
Quercetin: It binds and inhibits spike protein [74].
Apigenin: It binds and inhibits spike protein [74].
Nicotine: It disrupts glycosylation on spike protein and blocks possible spike protein-nicotinic cholinergic receptor interaction [75,76].
Emodin: It blocks the spike protein-ACE2 interaction [77].
Fisetin: It binds and inhibits spike protein [78].
Rutin: It binds and inhibits spike protein [79].
Silymarin: It binds and inhibits spike protein [80].
Towzerone wrote:Gaert Van derbussche said the other day the protocol of Natto Bromelaine etc that McCullough sells does NOTHING against the spike
ZERO ...its basically snake oil
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