https://www.cureus.com/articles/214853- ... nalysis#!/
.Discussion
This review highlights the effect of vitamin C supplementation in preventing the occurrence of PPROM and/or PROM in pregnant women. The pooled estimate effect was not significant to draw a possible conclusion on the role of this micronutrient. The high between-trial variation reflected by significant heterogeneity and degrees of bias however limit our evidence of conclusion to recommend a definite practice of implementation. But the subgroup analysis revealed that the supplementation of low-dose vitamin C, vitamin C monotherapy and vitamin C in women with a high risk of PPROM/PROM has definite benefits in preventing the obstetric complication